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At the same time the ratio of the serum concentrations of clarithromycin and its 14-OH metabolite was reversed from 3.3:1 to 1:2.7. There have been comparable, although less marked, adjustments after the addition of rifabutin 600 mg/day to a regimen that included clarithromycin one thousand mg/day.
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At the same time the ratio of the serum concentrations of clarithromycin and its 14-OH metabolite was reversed from 3.3:1 to 1:2.7. There have been comparable, although less marked, adjustments after the addition of rifabutin 600 mg/day to a regimen that included clarithromycin one thousand mg/day.
There have been no serious hostile events. There was some dispute as to whether toxicity was dose-associated or not, but it is wise to advocate that elderly patients should obtain an initial day by day dose of 1 g in this disease setting. Progressive loss of strength and issue in swallowing and eye opening after the primary dose of clarithromycin (2 g/day) occurred in a patient with cerebral toxoplasmosis and AIDS.
Two patients (aged 21 and 33 years) with late-stage AIDS had acute psychoses shortly after taking clarithromycin (2 g/day) for MAC bacteremia. Remedy regimens for patients with a positive tradition for MAC from a sterile site should include two or extra drugs, including clarithromycin.
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